Cathepsin S Is Required for Murine Autoimmune Myasthenia Gravis Pathogenesis
نویسندگان
چکیده
منابع مشابه
Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis.
Because presentation of acetylcholine receptor (AChR) peptides to T cells is critical to the development of myasthenia gravis, we examined the role of cathepsin S (Cat S) in experimental autoimmune myasthenia gravis (EAMG) induced by AChR immunization. Compared with wild type, Cat S null mice were markedly resistant to the development of EAMG, and showed reduced T and B cell responses to AChR. ...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2005
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.174.3.1729